CoQ10 for Statins, Heart, Oldies and much more

May 8, 2019
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What is CoQ10

Coenzyme Q10 is a naturally occurring vitamin-like substance that our bodies produce and is found in some foods. 

CoQ10 helps to convert food energy into cellular energy to be used for nearly every cell, tissue and organ in the body. A whopping 95% of our cells’ energy is dependent on CoQ10 (27), and accordingly cells with the highest energy demands, such as in the heart, muscle and liver have the highest levels.

As well as producing energy Coenzyme Q10 is an extremely powerful antioxidant which helps to protect body tissues against damage from toxic molecules known as free radicals which are produced as a by-product of energy production (20). As an antioxidant, it rivals vitamins E and C, actually helping to regenerate and recycle vitamin E. 

As we get older, we cannot convert CoQ10 as well. This can lead to lower cellular energy and less protection against damage from free radicals. Without enough CoQ10 to power our cells, they become less resilient and more susceptible to damage. 

Statins and CoQ10

Statin drugs in particular can lower CoQ10 levels by as much as 40% and supplementation with a high quality brand is highly advised. “statins inhibit one of the key steps in coenzyme Q10 synthesis. These drugs have been associated with a reduction in serum and muscle tissue coenzyme Q10 levels and may play a role in statin-induced myopathy” (6), “Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body.” (7)

Statins – “CoQ10 supplementation improve statin‐associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin‐induced myopathy” (5) (8) (16)

CoQ10 and Heart Health

75% of heart patients have severe deficiencies of CoQ10 in heart tissue compared with healthy individuals (12), so it is not surprisingly CoQ10 is well known for improving cardiovascular health, maintaining healthy heart function and reducing the risk of heart disease. In fact Professor Svend Aage Mortensen, Fellow of the European Society of Cardiology, researcher at the Heart Centre at the University Hospital, Copenhagen, Denmark said when speaking at the Heart Failure 2013 Congress: ‘CoQ10 is the first medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to standard heart failure therapy.’ (18)

Here’s just a few of the many major articles published in reputable medical journals on the use of coQ-10 for heart disease: 

  • heart rate and respiratory rate were significantly lowered, heart ejection fraction increased, walking distance on treadmill increased, distal edema decreased significantly (23)
  • 81% patients treated improved while taking CoQ10 (10)
  • significantly benefited three-fourths of a group of elderly patients with congestive heart failure. (12)
  • halved the risk of major adverse cardiovascular event, halved the risk of dying from all causes. (11) (18) (19)
  • All patients improved and 53% became asymptomatic after four weeks. (15)
  • The stroke index at rest and work improved significantly, the pulmonary artery pressure at rest and work decreased (significantly at rest), and the pulmonary capillary wedge pressure at rest and work decreased. (13)
  • Clinical benefits for 70 percent of the patients having congestive heart failure. (14)

So as you can see, maintaining high CoQ10 levels seems critical to sustaining health, particularly those who who are dealing with cardiovascular issues, are over 40, or taking statin drugs.

I have also provided some Clinical Studies showing CoQ10 benefits patients for: depression (1); cholesterol (1); Parkinson’s disease (1) (8); Fibromyalgia (1); Migraines (8); Conception (1a) (2) (3) (15); Breast cancer (28) (24) (25) (26); Athletes (4) (8) (17) (21) (22) 

Why Supplement?

Although CoQ10 is found mainly in meat, fish, seeds and whole grains, it isn’t enough to significantly increase CoQ10 levels in your body through diet alone, for example just 100g good quality supplement is similar to levels in a kilo of beef, half a kilo of sardines or a kilo of peanuts. (8) 

Supplementing with Coq10 has many benefits, with few negative side-effects (8) and as the body will use only what it needs and eliminate the excess, overdosing isn’t a high concern. However it is advised not to take while on  blood-thinning drugs such as Wafarin without medical advice due to potential interactions and as I always advise talk to your medical practitioner before starting anything new to check any other contradictions with your specific medications. Because coenzyme Q10 doesn’t cause side effects for most people, your doctor might suggest a trial of it to see if it helps you. 

Quality over Quantity

As with most supplements, you get what you pay for and top quality CoQ10 is not “cheap”. Although you may be tempted to choose a cheaper “off the shelf” product these often have the similar-sounding form “ubiquinone” which is more difficult for the body to convert compared to high quality, liquid capsules with bio-available ubiquinol.

This is the product I choose as it is clinically proven to deliver more CoQ10 to the bloodstream than solid formulations or from competitive liquid formulations, making USANA CoQuinone more bioavailable than other CoQ10 products, it delivers up to 4 times more to blood plasma than other brands.

Usana’s Coquinone™ is formulated with alpha lipoic acid a powerful antioxidant which attacks waste products created when the body turns food into energy. It also helps to recycle other antioxidants so that they become active again which helps to fight more free radicals.

See here or contact me if you would like further information on Coquinone 100.

References 

1 – https://examine.com/supplements/coenzyme-q10/

1a – https://www.ncbi.nlm.nih.gov/pubmed/19447425

2 – https://www.ncbi.nlm.nih.gov/pubmed/19509475

3 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870379/

4 –  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315638/

5 – https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009835

6 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/

7 – https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/expert-answers/coenzyme-q10/faq-20058176

8 – https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/art-20362602

9 – http://www.natap.org/2013/HIV/060513_02.htm

10 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807419/ 

11 – https://pdfs.semanticscholar.org/3a4c/6e3843bcae2269c92cc97eac369f59c47950.pdf

12 – https://www.dovepress.com/potential-role-of-coenzyme-q10-in-health-and-disease-conditions-peer-reviewed-fulltext-article-NDS

13 – https://www.ncbi.nlm.nih.gov/pubmed/10416042

14 – Healing with Vitamins: Straight from Nature, Backed by Science

15 – Textbook of Natural Medicine – E-Book

16 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226312/?tool=pmcentrez

17 – https://www.science.gov/topicpages/c/coenzyme+q10+supplementation.html

18 – http://www.escardio.org/about/press/press-releases/pr-13/Pages/first-drug-in-decade-improves-heart-failure-mortality.aspx 

19 – http://www.q-symbio.com/what-is-q-symbio

20 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807419/

21 – https://www.ncbi.nlm.nih.gov/pubmed/18284711

22 – https://www.ncbi.nlm.nih.gov/pubmed/21180141

23 https://www.ncbi.nlm.nih.gov/pubmed/20657530

24 http://www.cis.edu.rs/wp-content/uploads/2014/07/Coenzyme-Q10-Concentrations-and-Antioxidant-Status-in-Tissues-of-Breast-Cancer-Patients.pdf

25 https://www.semanticscholar.org/paper/Apparent-partial-remission-of-breast-cancer-in-with-Lockwood-Moesgaard/092cc08115273013f60e9210be37083c4a257f9a

26 https://www.ncbi.nlm.nih.gov/pubmed/7908519://www.ncbi.nlm.nih.gov/pubmed/19447425

27 https://www.quicksilverscientific.com/blog/coq10-one-solution-for-all-seasons/ https://foreveryoung.perriconemd.com/what-is-coq10.html

28 http://www.q10facts.com/more-about-coenzyme-q10-and-breast-cancer/

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